Cardiac Electrophysiology: From Cell To Bedside (7th Edition)

DescriptionRapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field.Key FeaturesAll chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics.New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations).Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online.New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text.Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.Table of ContentsSection 1 Structural and Molecular Bases of Ion Channel FunctionVoltage-Gated Sodium Channels and Electrical Excitability of the HeartVoltage-Gated CalciumVoltage-Gated Potassium ChannelsStructural and Molecular Bases of Cardiac Inward Rectifier Potassium Channel FunctionMammalian Calcium Pumps in Health and DiseaseStructural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel FunctionOrganellar Ion Channels and TransportersMolecular Organization, Gating and Function of Connexin-based Gap Junction Channels and HemichannelsSection 2 Biophysics of Cardiac Ion Channel FunctionStructure-function relations of Heterotrimetric complexes of sodium channel a and ss subunitsRegulation of Cardiac Calcium ChannelsInhibition of Phosphoinositide 3-Kinase and Acquired Long QT SyndromeStructural Determinants and Biophysical Properties of hERG1 Channel GatingMolecular Regulation of Cardiac Inward Rectifier Potassium Channels by Pharmacological AgentsCardiac Stretch-Activated Channels and Mechano-Electric CouplingBiophysical Properties of Gap JunctionsExcitation-Contraction CouplingSection 3 Intermolecular Interactions and Cardiomyocyte Electrical FunctionIon Channel Trafficking in the HeartMicrodomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5Fibroblast growth factor homologous factors modulate cardiac calcium channels.Macromolecular Complexes and Cardiac Potassium ChannelsReciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and ArrhythmiasThe intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion and cell excitabilityFunction and dysfunction of ion channel membrane trafficking and post translational modificationFeedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling.Section 4 Cell Biology of Cardiac Impulse Initiation and PropagationStem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: insights from sinoatrial node development and function.Gene Therapy and Biological PacingIntercellular Communication and Impulse PropagationMechanisms of normal and dysfunctional Sinoatrial Nodal Excitability and PropagationCell Biology of the Specialized Cardiac Conduction SystemCardiac Remodeling and RegenerationSection 5 Models of Cardiac ExcitationIonic Mechanisms of Atrial Action PotentialsGenetic algorithms to generate dynamical complexity electrophysiological modelsCalcium Signaling in Cardiomyocyte Models with Realistic GeometriesTheory of Rotors and ArrhythmiasComputational approaches for Accurate Rotor localization in the Human AtriaModeling the aging heartSection 6 Neural Control of Cardiac Electrical ActivityInnervation of the sinoatrial nodeMechanism for altered autonomic and oxidant regulation of cardiac sodium currents.Pulmonary Vein Ganglia and the Neural Regulation of the Heart RateNeural Activity and Atrial TachyarrhythmiasSympathetic Innervation and Cardiac ArrhythmiasSection 7 Arrhythmia MechanismsThe Molecular Pathophysiology of Atrial FibrillationMyofibroblasts, Cytokines, and Persistent Atrial FibrillationRole of the Autonomic Nervous System in Atrial FibrillationRotors in Human Atrial FibrillationBody surface frequency-phase mapping of atrial fibrillation.Panoramic Mapping of Atrial Fibrillation from the body surfaceMechanisms of Human Ventricular Tachycardia and Human Ventricular FibrillationGenetics of Atrial FibrillationSection 8 Molecular Genetics and PharmacogenomicsMechanisms in Heritable Sodium Channel DiseasesGenetic, Ionic and Cellular Mechanisms Underlying the J Wave SyndromesInheritable Potassium Channel DiseasesInheritable Phenotypes Associated With Altered Intracellular Calcium RegulationSection 9 Pharmacologic, Genetic and Cell Therapy of Ion Channel DysfunctionPharmacologic Bases of Antiarrhythmic TherapyPharmacogenomics of Cardiac ArrhythmiasGene therapy to treat cardiac arrhythmiasHighly Mature Human iPSC-Derived Cardiomyocytes as Models for Cardiac Electrophysiology and Drug TestingCardiac repair with human induced pluripotent stem cell-derived cardiovascular cells.Section 10 DIAGNOSTIC EVALUATIONAssessment of the patient with a cardiac arrhythmiaElectrocardiography of tachyarrhythmias: Differential diagnosis of narrow and wide QRS complex tachycardiasElectroanatomic Mapping for arrhythmiasComputed tomography for electrophysiologyMagnetic resonance imaging for electrophysiologyIntracardiac echocardiography for electrophysiologyExercise-induced arrhythmiasCardiac monitoring: short- and long-term recordingHead-up Tilt Table TestingAutonomic Regulation and Cardiac RiskT-wave alternansNoninvasive Electrocardiographic Imaging of Human Ventricular Arrhythmias and Electrophysiological SubstrateGenetic testingSection 11 SUPRAVENTRICULAR TACHYARRHYTHIAS: MECHANISMS, CLINICAL FEATURES, AND MANAGEMENTSinus node abnormalitiesAtrial tachycardiaAtrial tachycardia in adults with congenital heart diseaseTypical and Atypical Atrial Flutter: Mapping and AblationAtrial fibrillationPreexcitation, Atrioventricular reentry, VariantsElectrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Rentrant CircuitsJunctional tachycardiaSection 12 VENTRICULAR TACHYCARRHYTHMIAS: MECHANISMS, CLNICAL FEATURES, AND MANAGEMENTPremature ventricular complexesOutflow tract ventricular tachycardias: Mechanisms, Clinical Features, and ManagementFascicular ventricular arrhythmiasBundle branch reentry tachycardiaIschemic heart diseaseVentricular Tachycardia in Patients with Dilated CardiomyopathyVentricular Arrhythmias in Hypertrophic CardiomyopathyVentricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/CardiomyopathyVTs in Catcholaminergic Cardiomyopathy (Catecholaminergic polymorphic ventricular tachycardia)Ventricular Arrhythmias in Heart failureArrhythmias and conduction disturbances in Non Compaction CardiomyopathyTakotsubo cardiomyopathyBrugada syndromeLong and short QT syndromesAnderson-Tawil syndromeTimothy syndromeJ Wave SyndromesIdiopathic ventricular fibrillationSudden infant death syndromeSudden cardiac arrest/death in adultsNeurologic disordersDrug-Induced Ventricular TachycardiaVentricular Arrhythmias in Congenital Heart DiseaseSection 13 SYNCOPE and BradyarrhythmiasSyncopePostural orthostatic tachycardia syndromeProgressive conduction system diseaseAtrioventricular blockSection 14 ARRHYTHMIAS IN SPECIAL POPULATIONS PHARMACOLOGIC THERAPYSex differences in arrhythmiasSudden cardiac death in athletes, inlcuding commotio cordisPediatric populationsSleep-disordered breathing and arrhythmiasVentricular Assist devices and Cardiac Transplantation RecipientsSection 15 PHARMACOLOGIC THERAPYStandard antiarrhythmic drugsInnovations In Antiarrhythmic Drug TherapyNontraditional drugs for sudden cardiac deathPrevention of stroke in atrial fibrillation: warfarin, anti-factor Xa and thrombin drugsSection 16 CARDIAC IMPLANTABLE ELECTRONIC DEVICESImplantable cardioverter defibrillators: technical aspectsImplantable cardioverter defibrillators: clinical aspectsSubcutaneous implantable defibrillatorImplantable pacemakersCardiac resynchronization therapyNewer applications of pacemakersRemote monitoringSection 17 CATHETER ABLATIONCatheter Ablation: Technical aspectsCatheter Ablation: Clinical aspectsAblation for Atrial fibrillationAblation of Supraventricular tachycardiasCatheter Abliation for Ventricular tachycardias with/without structural heart diseaseEpicardial and other approachesVentricular fibrillationAblation in PediatricsCongenital heart diseaseAnesthesiology for EP proceduresSection 18: SURGERY FOR ARRHYTHMIASSurgery for Atrial fibrillation and other supraventricular tachycardiasSurgery for Ventricular tachycardiaSection 19 NEW APPROACHESCervical vagal stimulation for heart failureBaroreflex stimulationSpinal cord stimulation for heart failure and ArrhythmiasRenal artery denervationLeft atrial appendage occlusion/ligationAuthors BiographyDouglas ZipesAffiliations and ExpertiseDistinguished Professor, Division of Cardiology and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IndianaJose Jalife Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.Affiliations and ExpertiseDistinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.William Stevenson Dr Jalife is also actively conducting research at the Centro Nacional de Investigaciones Cardiovasculares, in Madrid, Spain. William Gregory Stevenson, MD, is Professor of Medicine at Vanderbilt University School of Medicine in Nashville, Tennessee. Dr Jalife will assume the role of lead editor on the 8th edition with Douglas Zipes’s retirementAffiliations and ExpertiseDirector, Cardiac Arrhythmia Program, Cardiovascular Division, Brigham and Women’s Hospital; Professor of Medicine Harvard Medical School, Boston, MA